Highlights •C. elegans neuronal small RNAs are characterized by RNA sequencing •RDE-4-dependent neuronal endogenous small RNAs communicate with the germline •Germline HRDE-1 mediates transgenerational regulation by neuronal small RNAs •Neuronal small RNAs regulate germline genes to control behavior transgenerationally Summary It is unknown whether the activity of the nervous system can be inherited. In Caenorhabditis elegans nematodes, parental responses…
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Nematodes, worms found in virtually all environmental habitats, are among the most studied model organisms. They reproduce quickly and their genome contains nearly the same number of genes as the human genome. A new Tel Aviv University study finds a mechanism exhibited in nematodes allows the nervous system cells — neurons — to communicate with…
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